Ivermectin in Japan

Antivirals in Japan

Ivermectin allowed as a treatment on August 13

Doctors can prescribe without restrictions

People can buy it legally from India

Dr. Haruo Ozaki, Chairman of the Tokyo Medical Association

https://www.tokyo-np.co.jp/article/123988

The situation is that the whole country is suffering from disasters.

No one will listen to me, so I will come up with a new policy

The antiparasitic drug "ivermectin" shows the number of infections and deaths of the new corona in a country that is prophylactically administered for another disease in Africa.

It is necessary to thoroughly study the clinical trial, but it seems that we are at the stage where it is okay to have the patient give an informed outlet and get permission to use it

Japan

https://www.japantimes.co.jp/news/2021/11/22/national/japan-coronavirus-november22/

Population, 126 million

Cases, + 79

Deaths, + 2

Lowest since June 23, 2020

Currently reopening

More than 76% of population is fully vaccinated

(South Korea, high vaccination but uptick in infections)

Boosters to start in December

Ingrained pre-pandemic flu seasons mask wearing

Delta variant wave ends

Delta variant “self-extinction”

Viral genetic mutations

Ituro Inoue, professor, National Institute of Genetics

Delta variant in Japan accumulated too many mutations

Virus’s error-correcting protein, nsp14

Majority of nsp14 specimens in Japan seemed to have undergone many genetic changes in mutation sites called A394V

Non-structural protein, made by the virus

Therefore errors accumulated leading to non-viability

Also

More people in Asia have a defense enzyme called APOBEC3A that attacks RNA viruses,

Including the SARS-CoV-2 virus that causes COVID-19,

when compared to people in Europe and Africa.

National Institute of Genetics and Niigata University

Research to discover how the APOBEC3A protein affects the nsp14 protein

A394V discovered in 24 other countries

SARS ended abruptly in 2003

Working on a drug to inhibit nsp14

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